The preclinical imaging core facility, led by Prof. Damien Huglo, is located on the campus of the University Hospital of Lille. In this recent years, technical evolution of in-vivo animal imaging has revived the prospects for health research. Our technical platform has two magnetic resonance imaging (MRI) equipment: one 0.2 tesla (Hitachi, Airis Mate) dedicated to big animals (sheep and pigs) and a 7 teslas (Bruker, Biospec) dedicated to rodents (rats and mice). MR technique provides relevant information to assess the effect of new therapeutic treatment, intoxication or molecule biodistribution. Our preclinical team consists of 2 engineers, one of whom is specialized in the definition and implementation of experimental protocols, and the other in data processing and the development of computer tools related to medical imaging. A qualified technician for pre-clinical experiments also brings his expertise during the acquisition sessions.

Expertise field

• Quantification of biological phenomena by MR relaxometry, diffusion and spectroscopy
• Morphological exploration of organs by MRI
• Data processing and development of computer tools related to preclinical medical imaging

Current projects

• Etude de Grégory Kuchinsky (Régis Bordet), imagerie en T2* de 8 tubes contenant des concentrations différentes de fer, 5 passages effectués afin d'éprouver la reproductibilité de la méthode. Le post-traitement sera effectué sur le plateau clinique via le script "QSM"
• Etude de Bénédicte Vanteghem (Patrick Vermersch) sur la quantification de la démyélinisation du corps calleux (résultats de fin d'étude prévue le 22 décembre). Clémence a pris quelques données de ce projet pour se familiariser avec les fichiers Bruker et travailler sur la possibilité d'extraire les données de diffusion au sein du corps calleux des souris de manière "automatique".
• Etude des microhémorragies disséminées (Thèse de Maud Pétrault, Equipe R.Bordet). Post-traitement par QSM